What are the chances of in vitro fertilization?

The success probability of in vitro fertilization is usually between 30% and 50%, which is related to factors such as female age, ovarian function, and embryo quality. Factors that affect the success rate of in vitro fertilization mainly include egg quality, endometrial receptivity, laboratory technical conditions, sperm motility, and underlying diseases of the patient.

1. Egg quality

Before the age of 35, the egg quality of women is better, and the success rate of in vitro fertilization can reach more than 40%. As age increases, the probability of egg chromosomal abnormalities increases, and the success rate for women over 40 years old may drop to about 20%. Ovarian reserve function can be assessed through anti-Müllerian hormone testing. Values ​​below 1.1ng/ml indicate ovarian hypofunction.

2. Endometrial receptivity

The thickness of the endometrium is 8-14mm, which is most suitable for embryo implantation. Too thin or too thick will reduce the success rate. When there are problems such as endometritis, endometrial polyps or adhesions, hysteroscopic treatment is required first. Some patients need to use estrogen drugs to regulate the endometrial growth cycle.

3. Laboratory technical conditions

The embryo laboratory needs to maintain a constant temperature and humidity environment, and the carbon dioxide concentration in the incubator needs to be stable at about 6%. The embryologist's operating experience directly affects the fertilization rate and high-quality embryo rate. Blastocyst culture technology can increase the implantation rate to more than 50%. Some centers use time-lag microscopy imaging systems to screen embryos with the greatest developmental potential.

4. Sperm motility

Patients with severe oligoasthenozoospermia need to use intracytoplasmic sperm injection technology to complete fertilization. Sperm DNA fragmentation rate exceeding 30% may lead to fertilization failure or early miscarriage. In such cases, antioxidant treatment is recommended first. Semen optimization processing technology can effectively screen sperm with high motility.

5. Basic disease management

Patients with polycystic ovary syndrome need to adjust their hormone levels first, and those with thyroid dysfunction should control their TSH below 2.5mIU/L. Patients with endometriosis stage III or above are recommended to undergo laparoscopic surgery first, and patients with diabetes need to control their glycated hemoglobin within 7%. Once these underlying diseases are controlled, the success rate of IVF can be significantly improved.

You need to quit smoking and drinking 3 months before IVF, and avoid contact with toxic chemicals. Women can appropriately supplement coenzyme Q10 to improve egg quality, and men can increase zinc and selenium intake to improve sperm motility. During treatment, you should maintain a regular schedule and avoid strenuous exercise and mental stress. After each transplant, luteal support drugs should be used as directed by the doctor. 14 days after the transplant, blood should be drawn to test HCG to confirm pregnancy. If the first transplantation is unsuccessful, you can analyze the reasons for the failure with your reproductive doctor, adjust the plan, and perform a frozen embryo transfer or a new round of ovulation induction.