Contraceptive injections have high success rate and many side effects

　　Many couples have quarrels over who is responsible for contraception, and many have broken up. After all, there are only two kinds now male Contraceptive methods – condoms and vasectomy, of course, have their drawbacks. For example, condoms have a very high success rate of 98%, but there are still people who are not very good at using them correctly, so the success rate drops to 85%. Another option is vasectomy, which is a permanent procedure, but men bear the risk of postoperative complications such as bleeding, infection, painful nodules, and epididymostasis.

　　However, within the next five years, male contraception that involves a shot in the butt may become more common.

　　Testosterone contained in contraceptive injections is the most active male hormone. sperm It is very important for the production of male reproductive organs, maintains male secondary sexual characteristics and sexual desire, and promotes the growth of sperm. However, large doses of testosterone will cause excessive testosterone in the body. Through a feedback mechanism, it first inhibits the secretion of gonadotropins from the hypothalamus and adenohypophysis, and then inhibits the synthesis of androgens and spermatogenesis in the testicles.

　　Relevant researchers conducted a two-year trial in China involving 1,000 injectors. The final result was that the success rate in preventing pregnancy reached 95%. Six months after stopping the injections, all but two men's sperm counts returned to normal levels.

　　While the results appear promising, one-third of men still give up on this form of contraception, unwilling to take the monthly injections and the potential side effects, including mood swings, reduced libido, and acne.

　　In addition, previous studies have shown that Asian men are more sensitive to testosterone than Europeans, which may be related to the latter's genes and lower body mass index. Therefore, in the West, if you want to suppress sperm production, you may need to add other hormones (such as progesterone) together. “Five percent of men's sperm count may not drop below a level that would make it an effective form of contraception," said Professor Peter Schlegel, chief of urology at Cornell University in New York and a leader in male contraception. "In addition, it takes a two to three month lag period for all sperm production to stop, during which time the couple needs to use other contraceptive methods. ”This approach could be operational within five years.

　　Currently, British researchers are developing a male contraceptive pill (paralysing pill) that can prevent men from ejaculating sperm during orgasm. This preparation contains certain compounds from blood pressure drugs and psychiatric drugs used in the 1960s. It can temporarily paralyze certain muscles in the male reproductive system in a short period of time, causing the release of semen to fail. However, it will not cause a loss of sexual desire, nor will it reduce sexual performance and sensation. Men will also have orgasms and pleasure, but there will be no fluid outflow. However, this approach may cause "dry ejaculation ”Wait for side effects.

　　Medical researchers at King's College London said the drug works within three hours of taking it and lasts for two days, so it only needs to be taken when needed.

　　Emeritus Professor, Family Planning and Reproduction, University of London healthy Expert Professor John Varvatos Guillebaud said that with sufficient research funding, this method could be used within ten years.