6 types of drugs that can cause birth control pills to malfunction

　　Oral contraceptive pills are a simple and easy contraceptive method, but taking certain drugs at the same time as birth control pills can cause contraceptive failure. The editor below introduces 6 kinds of medicines that cannot be taken with birth control pills to avoid interfering with the effect of birth control pills.

　　rifampicin

　　It is a commonly used anti-tuberculosis drug. It can accelerate the metabolism of norethindrone and ethinyl estradiol, the main components of oral contraceptives, reduce the drug concentration in the blood, and may also cause Uterus Part of the endometrium falls off, causing spotting or bleeding, and at the same time, the efficacy of contraceptive drugs is reduced, resulting in contraceptive failure.

　　antibiotics

　　Someone once observed 38 women who were taking birth control pills while taking ampicillin, neomycin, tetracycline, trimethoprim-sulfamethoxazole, and chloramphenicol, and found that the reason for their pregnancy was that the antibiotics inhibited the intestinal bacteria, causing the production of Grape The amount of uronidase is greatly reduced, which affects the absorption of contraceptive pills in the intestines and reduces the concentration of contraceptive pills in the blood.

　　anti- epilepsy medicine

　　This type of drugs is enzyme inducers, such as phenobarbital, phenytoin, carbamazepine, epilepticone, etc. When women with epilepsy take such drugs, they can promote the increase of drug-replacement enzymes in liver cells, accelerate the destruction of oral contraceptives, and also increase the binding rate of progesterone and globulin, greatly reducing the concentration of free drugs, leading to the failure of contraceptive pills.

　　griseofulvin

　　It is an antifungal drug. When used together with contraceptives, it can change the activity of liver microsomal enzymes, reduce steroid hormones and cause menstrual blood loss, leading to contraceptive failure.

　　Enzyme accelerator

　　Such as sedatives and sleeping pills such as metoprolol, and drugs for treating rheumatoid arthritis such as phenylbutazone. These drugs have enzymatic effects, which can promote the metabolic activity of liver microsomal enzymes, accelerate the metabolism of oral contraceptives, and reduce the contraceptive effect. If sleeping pills must be used, diazepam can be used instead.

　　hormone

　　Such as dexamethasone, etc., which may increase when taking birth control pills at the same time skin Although it has the function of hormones, it can also delay the metabolism of corticosteroids and greatly increase its side effects.