Beware of 5 types of medicines that may cause contraceptive ineffectiveness

　　1. Resistance epilepsy medicine
　　
This type of drug is an enzyme inducer, such as phenobarbital, phenytoin, carbamazepine, epilepticone, etc. When women with epilepsy take such drugs, they can increase the amount of drug-metabolizing enzymes in liver cells, accelerating the destruction of the efficacy of oral contraceptives, and also increase the binding rate of progesterone to globulin, greatly reducing the concentration of free progesterone, leading to contraceptive ineffectiveness.

2. Antibiotics
　　
Someone once observed 38 women who took birth control pills and used ampicillin, neomycin, tetracycline, trimethoprim-sulfamethoxazole, and chloramphenicol at the same time, resulting in contraceptive failure. It was found that the reason for the failure was that the antibiotics inhibited the intestinal bacteria, causing them to produce Grape The amount of uronidase is greatly reduced, which affects the absorption of contraceptive pills in the intestines, causing the concentration of contraceptive pills in the blood to decrease and failing to achieve the contraceptive effect.

3. Enzyme accelerator
　　
For example, sedatives and sleeping pills such as metoprolol, and drugs for treating rheumatoid arthritis such as phenylbutazone. These drugs have enzymatic effects, which can promote the metabolic activity of drugs catalyzed by liver mitochondrial enzymes, accelerate the metabolism of oral contraceptives, and reduce the contraceptive effect. If sleeping pills must be used, diazepam can be used instead. Do not take other sedative and sleeping pills.

　4. Rifampicin
　　
It is a commonly used anti-tuberculosis drug. It can accelerate the metabolism of norethindrone and ethinyl estradiol, the main components of oral contraceptives, reduce the drug concentration in the blood, and may also cause Uterus Part of the endometrium may fall off, causing spotting or dripping, and at the same time, the efficacy of the contraceptive pill may be reduced, resulting in contraceptive failure.

5. Griseofulvin
　　
This is an antifungal drug. When used together with contraceptive pills, it can change the activity of liver granulase, causing the concentration of steroid hormones to decrease, resulting in decreased menstrual blood, leading to contraceptive failure. It has been reported abroad that among more than 20 women taking birth control pills, 15 had reduced menstrual blood volume and 5 had menstrual bleeding after taking griseofulvin. amenorrhea , 2 are pregnant.